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Fentanyl 100 µg/uur Teva

Use treatment of chronic stabilized moderate to severe pain (level 3 on the WHO pain ladder), as an alternative to subcutaneous or oral administration of morphine (for refractory adverse effects or swallowing disorders)
neuropathic pain.


Unwanted Effects

the most common are: nausea, vomiting, constipation, hypotension, bradyardia, confusion, excessive sweating and urinary retention; there is progressive tolerance to these unwanted effects (except for constipation)
sedation and respiratory depression (if they persist or recur, this may be a sign of overdose)
skin reactions such as rash, erythema and itching


+ alcohol and centrally sedating drugs: enhancement of the sedative effect

+ morphine agonist antagonists (buprenorphine, pentazocine): reducing the analgesic effect by competition for receptors, with a risk of withdrawal symptoms

+ inducers of CYP3A4 (see CYP 450): risk of reducing the effect of fentanyl

+ inhibitors of CYP3A4 (see CYP 450): risk of fentanyl accumulation and increased adverse effects

+ drugs with bradycardizing effect: (amiodarone, sotalol, diltiazem, verapamil, clonidine, moxonidine): increase the risk of QT interval prolongation

+ drugs with serotoninergic activity: MAO inhibitors, amitriptyline, SSRIs, dextrometorphan, tramadol, triptans, St. John’s wort: increased risk of serotonin syndrome

+ drugs that can cause constipation or intestinal obstruction: increase the risk of constipation


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