Doses greater than 200 micrograms are solely for use in anesthesia.
As a premedical, 1 – 2ml may be administered intramuscularly before induction of anesthesia.
Following intravenous administration in the non-premedicated adult patient, 2ml fentanyl may be anticipated to provide adequate analgesia for 10 – 20 minutes in surgical procedures involving low pain intensity. A bolus of 10ml of fentanyl can be expected to provide analgesia for about one hour. The analgesia produced is generally adequate for surgery involving moderate pain intensity. Administration of 50 microgram/kg will provide intense analgesia for some four to six hours for surgery associated with intense stimulation.
Fentanyl 50 micrograms/ml Solution for Injection/Infusion may also be administered as an intravenous infusion.
Ventilated patients may be given a loading dose as a fast infusion of approximately 1 microgram/kg/minute for the first 10 minutes, followed by an infusion of approximately 0.1 microgram/kg/minute. Alternatively, the loading dose may be administered as a bolus. The rate of infusion should be titrated to the individual patient response and slower infusion rates may be adequate. The infusion should be discontinued approximately 40 minutes before the end of surgery unless postoperative ventilation is intended.
Lower infusion rates, e.g. 0.05 – 0.08 microgram/kg/minute, are required if spontaneous ventilation is to be maintained. Higher infusion rates of up to 3 micrograms/kg/minute have been employed in cardiac surgery.
It is important when estimating the required dose to assess the likely degree of surgical stimulation, the effect of premedical drugs, and the duration of the procedure.
Children aged 12 to 17 years old- Follow adult dosage:
Children aged 2 to 11 years old: